Striatal dopamine D_2/3 receptors in medication-naive schizophrenia: an [¹²³I] IBZM SPECT study.

ABSTRACT:

Background

The hyper-function of the striatal dopamine system has been suggested to underlie key pathophysiological mechanisms in schizophrenia. Moreover, patients have been observed to present a significant elevation of dopamine receptor availability compared to healthy controls. Although it is difficult to measure dopamine levels directly in humans, neurochemical imaging techniques such as single-photon emission computed tomography (SPECT) provide indirect indices of in vivo dopamine synthesis and release, and putative synaptic levels.

Methods

We focused on the role of dopamine postsynaptic regulation using [123I] iodobenzamide (IBZM) SPECT. We compared D2/3 receptor availability between 53 healthy controls and 21 medication-naive patients with recent-onset schizophrenia.<

SUBMITTER: Chen KC 

PROVIDER: S-EPMC9693693 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature