Ultrasensitive dopamine detection with graphene aptasensor multitransistor arrays.

ABSTRACT: Detecting physiological levels of neurotransmitters in biological samples can advance our understanding of brain disorders and lead to improved diagnostics and therapeutics. However, neurotransmitter sensors for real-world applications must reliably detect low concentrations of target analytes from small volume working samples. Herein, a platform for robust and ultrasensitive detection of dopamine, an essential neurotransmitter that underlies several brain disorders, based on graphene multitransistor arrays (gMTAs) functionalized with a selective DNA aptamer is presented. High-yield scalable methodologies optimized at the wafer level were employed to integrate multiple graphene transistors on small-size chips (4.5 × 4.5 mm). The multiple sensor array configuration permits independent and s

SUBMITTER: Abrantes M 

PROVIDER: S-EPMC9694542 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature