Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations.

ABSTRACT: Vitamin D (VD) is a fat-soluble vitamin, and pivotal for maintaining health. Several genetic markers have been related to a deficient VD status; these markers could confer an increased risk to develop osteoporosis and other chronic diseases. A VD deficiency could also be a determinant of a severe COVID-19 disease. This study aimed to interrogate genetic/biological databases on the biological implications of a VD deficiency and its association with diseases, to further explore its link with COVID-19. The genetic variants of both a VD deficiency and COVID-19 were identified in the genome-wide association studies (GWAS) catalog and other sources. We conducted enrichment analyses (considering corrected p-values < 0.05 as statistically significant) of the pathways, and gene-disease associations

SUBMITTER: Alcala-Santiago A 

PROVIDER: S-EPMC9699081 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature