Late-Life Depression is Associated With Increased Levels of GDF-15, a Pro-Aging Mitokine.

ABSTRACT:

Objective

In older adults, major depressive disorder (MDD) is associated with accelerated physiological and cognitive aging, generating interest in uncovering biological pathways that may be targetable by interventions. Growth differentiation factor-15 (GDF-15) plays a significant role in biological aging via multiple biological pathways relevant to age and age-related diseases. Elevated levels of GDF-15 correlate with increasing chronological age, decreased telomerase activity, and increased mortality risk in older adults. We sought to evaluate the circulating levels of GDF-15 in older adults with MDD and its association with depression severity, physical comorbidity burden, age of onset of first depressive episode, and cognitive performance.

Design

This study assayed circu

SUBMITTER: Mastrobattista E 

PROVIDER: S-EPMC9701166 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature