Dataset Information

Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study.

ABSTRACT:

Background

Evidence regarding the impact of education on diabetes risk is scarce in developing countries. We aimed to explore the association between education and diabetes within a large population in China and to identify the possible mediators between them.

Methods

Information on educational level and lifestyle factors was collected through questionnaires. Diabetes was diagnosed from self-report and biochemical measurements. A structural equation model was constructed to quantify the mediation effect of each mediator.

Results

Compared with their least educated counterparts, men with college education had a higher risk of diabetes (odds ratio [OR] 1.19; 95% confidence interval [CI], 1.12-1.27), while college-educated women were less likely to have diabetes (OR 0.77; 95% CI, 0.73-0.82). Obesity was the strongest mediator in both genders (proportion of mediation: 11.6% in men and 23.9% in women), and its association with education was positive in men (β[SE] 0.0387 [0.0037]) and negative in women (β[SE] -0.0824 [0.0030]). Taken together, all behavioral factors explained 12.4% of the excess risk of diabetes in men and 33.3% in women.

Conclusions

In a general Chinese population, the association between education level and diabetes was positive in men but negative in women. Obesity was the major mediator underlying the education disparities of diabetes risk, with a stronger mediation effect among women.

SUBMITTER: Zhu Y

PROVIDER: S-EPMC9705800 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study.

Zhu Yuanyue Y Hu Chunyan C Lin Lin L Wang Shuangyuan S Lin Hong H Huo Yanan Y Wan Qin Q Qin Yingfen Y Hu Ruying R Shi Lixin L Su Qing Q Yu Xuefeng X Yan Li L Qin Guijun G Tang Xulei X Chen Gang G Xu Min M Xu Yu Y Wang Tiange T Zhao Zhiyun Z Gao Zhengnan Z Wang Guixia G Shen Feixia F Luo Zuojie Z Chen Li L Li Qiang Q Ye Zhen Z Zhang Yinfei Y Liu Chao C Wang Youmin Y Wu Shengli S Yang Tao T Deng Huacong H Chen Lulu L Zeng Tianshu T Zhao Jiajun J Mu Yiming Y Wang Weiqing W Ning Guang G Bi Yufang Y Chen Yuhong Y Lu Jieli J

Journal of diabetes 20221011 11

<h4>Background</h4>Evidence regarding the impact of education on diabetes risk is scarce in developing countries. We aimed to explore the association between education and diabetes within a large population in China and to identify the possible mediators between them.<h4>Methods</h4>Information on educational level and lifestyle factors was collected through questionnaires. Diabetes was diagnosed from self-report and biochemical measurements. A structural equation model was constructed to quanti ...[more]

PMID: 36217863

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Project description:Genomic expression profiles of blood and placenta reveal significant immune-related pathways and categories in Chinese women with Gestational Diabetes Gestational diabetes mellitus (GDM) is a complex metabolic disease which occurs in pregnancy with high prevalence, and its pathogenesis remains elusive. Thus far, there has been no comprehensive gene expression profiling in Chinese women with GDM. In this study, we attempt to define the genes and/or pathways that are involved in GDM with Chinese ethnicity, by the Illumina microarray technique. We found 5,197 and 243 genes with significantly altered expression due to GDM in blood and placenta tissues, respectively. Previously known genes (such as TNF, IL1B, LEP, IFNG, and HLA-G) with altered gene expression in GDM were also validated here. In addition, we identified undescribed genes VAV3, PTPN6, CD48 and IL15, in which expression was related to GDM by microarray and Q-RT-PCR assays. To identify GDM-associated pathways, we used analyses with integrated functional annotation (i.e. KEGG) and extracted two significant pathways, which were Natural killer cell mediated cytotoxicity (hsa04650; FDR = 7.10E-09) in blood and Cytokine-cytokine receptor interaction (hsa04060; FDR = 1.07E-03) in placenta tissues. Immune system process (GO: 0002376) was identified by GO analysis with FDR P-value = 7.01E-60 in blood and FDR P-value = 3.57E-08 in placenta tissues, indicating the importance of immunological and inflammatory categories in GDM. Furthermore, despite differences in the quantity of gene expression, we observed a similar functional distribution between expression of blood and placenta tissues in GDM under the categories of immunity. These newly identified key genes and pathways may provide valuable information for the pathogenesis of GDM and advance disease diagnosis, prevention, medication design, and clinical treatment of the disease. One individual GDM blood tissue sample and one pooled GDM blood tissue sample were compared to one pooled healthy blood tissue sample. One pooled GDM placenta tissue sample was compared to one pooled healthy placenta tissue sample.

Dataset Information

Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study.

Background

Methods

Results

Conclusions

Publications

Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study.

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