Association of Body Mass Index With 21-Gene Recurrence Score Among Women With Estrogen Receptor-Positive, ERBB2-Negative Breast Cancer.

ABSTRACT:

Importance

Body mass index (BMI) may affect the 21-gene recurrence score (RS) in patients with ER-positive, ERBB2-negative breast cancer. If high BMI increases genomic risk in ER-positive, ERBB2-negative breast cancer, weight control will become more important.

Objective

To assess the association between RS and BMI according to age groups and address BMI as a factor associated with high RS.

Design, setting, and participants

This cohort study included 2295 patients with ER-positive, ERBB2-negative breast cancer who had undergone a multigene assay between March 29, 2010, and December 31, 2020, in 2 hospitals. All of the study patients were Korean women, and the median follow-up period was 45 months (range, 1-40 months). The correlations between continuous RS and BMI wer

SUBMITTER: Lee J 

PROVIDER: S-EPMC9706366 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature