Growth Rate and Thermal Properties of DNA Origami Filaments.

ABSTRACT: Synthetic DNA filaments exploit the programmability of the individual units and their predictable self-association to mimic the structural and dynamic features of natural protein filaments. Among them, DNA origami filamentous structures are of particular interest, due to the versatility of morphologies, mechanical properties, and functionalities attainable. We here explore the thermodynamic and kinetic properties of linear structures grown from a ditopic DNA origami unit, i.e., a monomer with two distinct interfaces, and employ either base-hybridization or base-stacking interactions to trigger the dimerization and polymerization process. By observing the temporal evolution of the system toward equilibrium, we reveal kinetic aspects of filament growth that cannot be easily captured by posta

SUBMITTER: Stenke LJ 

PROVIDER: S-EPMC9706658 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature