Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections.

ABSTRACT: One of the biggest threats for bacteria-based bioreactors in the biotechnology industry is infections caused by bacterial viruses called bacteriophages. More than 70% of companies admitted to encountering this problem. Despite phage infections being such a dangerous and widespread risk, to date, there are no effective methods to avoid them. Here we present a peptide-grafted compounds that irreversibly deactivate bacteriophages and remain safe for bacteria and mammalian cells. The active compounds consist of a core (cyclodextrin or gold nanoparticle) coated with a hydrophobic chain terminated with a peptide selective for bacteriophages. Such peptides were selected via a phage display technique. This approach enables irreversible deactivation of the wide range of T-like phages (including the

SUBMITTER: Richter L 

PROVIDER: S-EPMC9706661 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature