An fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive-compulsive disorder.

ABSTRACT:

Background

Pediatric obsessive-compulsive disorder (OCD) has been associated with poorer planning in laboratory, school and home settings. It is unclear whether this impairment is a standalone cognitive issue or the result of OCD symptoms. No study has examined the influence of provoked distress on planning performance and neural correlates in pediatric OCD.

Methods

Before and after a symptom provocation task, youth with OCD (n = 23; 9 boys; mean age ± standard deviation 15.1 ± 2.6 years) and matched healthy controls (n = 23) completed the Tower of London task during functional MRI scanning.

Results

During planning, participants with OCD recruited the left superior frontal gyrus to a greater extent than healthy controls after symptom provocation (group ×

SUBMITTER: Jaspers-Fayer F 

PROVIDER: S-EPMC9710544 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature