Non-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy.

ABSTRACT:

Objective

To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE).

Study design

Prospective observational study of 44 infants with HIE (23 mild, 17 moderate, 4 severe) and 17 term controls. Infants with HIE had non-invasive CO monitoring (NICOM) continuously in the neonatal unit. Term controls had NICOM recorded at 6 and 24 h. A mixed-modelling approach was used to assess change in CO over time by group.

Results

Infants with moderate HIE have significantly lower CO than the mild group at all timepoints (10.7 mls/kg/min lower, 95% CI:1.0,20.4, p = 0.03) which increases over time, driven by a gradual increase in stroke volume (SV). CO increased further during rewarming pre

SUBMITTER: Garvey AA 

PROVIDER: S-EPMC9712087 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature