Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.

ABSTRACT:

Background

Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.

Objective

To study the cross-sectional associations of pulmonary function with structural brain variables.

Methods

Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities

SUBMITTER: Frenzel S 

PROVIDER: S-EPMC9712227 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature