Free-breathing 3D CEST MRI of human liver at 3.0 T.

ABSTRACT:

Purpose

To develop a novel 3D abdominal CEST MRI technique at 3 T using MR multitasking, which enables entire-liver coverage with free-breathing acquisition.

Methods

k-Space data were continuously acquired with repetitive steady-state CEST (ss-CEST) modules. The stack-of-stars acquisition pattern was used for k-space sampling. MR multitasking was used to reconstruct motion-resolved 3D CEST images of 53 frequency offsets with entire-liver coverage and 2.0 × 2.0 × 6.0 mm³ spatial resolution. The total scan time was 9 min. The sensitivity of amide proton transfer (APT)-CEST (magnetization transfer asymmetry [MTR_asym ] at 3.5 ppm) and glycogen CEST (glycoCEST) (mean MTR_asym around 1.0 ppm) signals generated with the proposed method were tested wi

SUBMITTER: Han P 

PROVIDER: S-EPMC9712251 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature