Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice.

ABSTRACT: While androgen is considered a pivotal regulator of sexually dimorphic development, it remains unclear how it orchestrates the differentiation of reproductive organs. Using external genitalia development as a model, we showed that androgen, through the transcription factor MafB, induced cell migration by remodeling the local extracellular matrix (ECM), leading to increased cell contractility and focal adhesion assembly. Furthermore, we identified the matrix metalloproteinase Mmp11 as a MafB target gene under androgen signaling. MMP11 remodels the local ECM environment by degrading Collagen VI (ColVI). The reduction of ColVI led to the fibrillar deposition of fibronectin in the MafB-expressing bilateral mesenchyme both in vivo and ex vivo. The ECM r

SUBMITTER: Alcantara MC 

PROVIDER: S-EPMC9713376 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature