Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains.

ABSTRACT:

Background

Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an early developmental deficiency with a more specifically neurodevelopmental origin. Understanding the timepoints of disturbances during neural cell differentiation processes could lead to an insight into the development of the disorder. In this context, human brain organoids and neural cells differentiated from patient-derived induced pluripotent stem cells are of great interest as a model to study the developmental origins of the disease.

Results

Here we evaluated the differential expression of proteins of schizophrenia patient-derived neural progenitors (NPCs

SUBMITTER: Nascimento JM 

PROVIDER: S-EPMC9714120 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature