Integrative metabolic analysis of orbital adipose/connective tissue in patients with thyroid-associated ophthalmopathy.

ABSTRACT:

Objective

Thyroid-associated ophthalmopathy (TAO) is a disfiguring autoimmune disease, which destroys the structure of orbital tissues and even threatens vision. Metabolic reprograming is critical in autoimmune diseases; however, the metabolic basis of TAO remains to be clarified. Our study aimed to reveal the metabolic profile of TAO.

Methods

Orbital adipose/connective tissues from eleven TAO patients and twelve control subjects were collected during surgeries and analyzed with liquid chromatograph-mass spectrometer. Orthogonal partial least-squares discrimination analysis (OPLS-DA), variable importance in projection (VIP), heat map, and volcano plot were used to reveal metabolic profile in TAO. Pathway analysis and metabolites-gene analysis were utilized to explore potenti

SUBMITTER: Huang J 

PROVIDER: S-EPMC9718489 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature