Cardiac Valve Disease and Prevalent and Incident CKD in Community-Dwelling Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Rationale & objective

Recent literature suggests improvement in kidney function after percutaneous valvular replacement therapies, implying a pathophysiological contribution of valvular heart disease to chronic kidney disease (CKD). However, this association has not been investigated epidemiologically. We aimed to assess the association of valvular abnormality with prevalent and incident CKD.

Study design

Cross-sectional and prospective analyses.

Setting & participants

Community-dwelling participants (mean age 75.5 [standard deviation 5.1] years) from the Atherosclerosis Risk in Communities study (2011-2013).

Exposure

Valvular abnormality defined as echocardiography-based aortic stenosis, aortic regurgitation, and mitral regurgitation.

Outcomes

Prevalent

SUBMITTER: Karandikar VM 

PROVIDER: S-EPMC9722472 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature