Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5).

ABSTRACT:

Aim

Metabolic syndrome (MS) refers to a group of co-morbidities which include central obesity, hypertension, hyperglycemia and dyslipidemia. Previously, we reported that childhood lymphatic filariasis (LF) confers significant protection against type-1 and type-2 forms of diabetes, by means of immunomodulation. In the present study, we studied the effect of LF on endocrine dysfunction in MS and Non-MS patients in baseline and after 10 years of follow-up.

Methods

We quantified the serum levels of pancreatic hormones (insulin and glucagon), incretins (Ghrelin, GIP and GLP-1) and adipokines (leptin, adiponectin, adipsin, visfatin, PAI-1 and resistin) by multiplex bead array system.

Results

MS (both LF- and LF+) subjects had increased insulin levels compared to NMS (both L

SUBMITTER: Sibi JM 

PROVIDER: S-EPMC9723321 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature