TMBIM5 is the Ca²⁺ /H⁺ antiporter of mammalian mitochondria.

ABSTRACT: Mitochondrial Ca²⁺ ions are crucial regulators of bioenergetics and cell death pathways. Mitochondrial Ca²⁺ content and cytosolic Ca²⁺ homeostasis strictly depend on Ca²⁺ transporters. In recent decades, the major players responsible for mitochondrial Ca²⁺ uptake and release have been identified, except the mitochondrial Ca²⁺ /H⁺ exchanger (CHE). Originally identified as the mitochondrial K⁺ /H⁺ exchanger, LETM1 was also considered as a candidate for the mitochondrial CHE. Defining the mitochondrial interactome of LETM1, we identify TMBIM5/MICS1, the only mitochondrial member of the TMBIM family, and validate the physical interaction of TMBIM5 and LETM1. Cell-based and cell-free biochemical a

SUBMITTER: Austin S 

PROVIDER: S-EPMC9724676 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature