MicroRNA mimics can distort physiological microRNA effects on immune checkpoints by triggering an antiviral interferon response.

ABSTRACT: The microRNA-200 family has wide-ranging regulatory functions in cancer development and progression. Above all, it is strongly associated with the epithelial-to-mesenchymal transition (EMT), a process during which cells change their epithelial to a mesenchymal phenotype and acquire invasive characteristics. More recently, miR-200 family members have also been reported to impact the immune evasion of cancer cells by regulating the expression of immunoinhibitory immune checkpoints (ICs) like PD-L1. Therefore, we aimed to comprehensively characterize this miR-200 family as a regulatory interface between EMT and immune evasion mechanisms in biliary tract cancer. Initial correlation analyses and transient overexpression experiments using miRNA mimics suggested miR-200c-3p as a putative regulato

SUBMITTER: Prinz F 

PROVIDER: S-EPMC9728468 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature