Methylation of the serotonin reuptake transporter gene and non-motor symptoms in dystonia patients.

ABSTRACT:

Background

Dystonia is a rare movement disorder, in which patients suffer from involuntary twisting movements or abnormal posturing. Next to these motor symptoms, patients have a high prevalence of psychiatric comorbidity, suggesting a role for serotonin in its pathophysiology. This study investigates the percentage of DNA methylation of the gene encoding for the serotonin reuptake transporter (SLC6A4) in dystonia patients and the associations between methylation levels and presence and severity of psychiatric symptoms.

Methods

Patients with cervical dystonia (n = 49), myoclonus dystonia (n = 41) and dopa-responsive dystonia (DRD) (n = 27) and a group of healthy controls (n = 56) were included. Psychiatric comorbidity was evaluated with validated questionnaires. Methylation

SUBMITTER: Timmers ER 

PROVIDER: S-EPMC9743677 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature