Deletion of the voltage-gated calcium channel, Ca_V 1.3, causes deficits in motor performance and associative learning.

ABSTRACT: L-type voltage-gated calcium channels are important regulators of neuronal activity and are widely expressed throughout the brain. One of the major L-type voltage-gated calcium channel isoforms in the brain is Ca_V 1.3. Mice lacking Ca_V 1.3 are reported to have impairments in fear conditioning and depressive-like behaviors, which have been linked to Ca_V 1.3 function in the hippocampus and amygdala. Genetic variation in Ca_V 1.3 has been linked to a variety of psychiatric disorders, including autism and schizophrenia, which are associated with altered motor learning, associative learning and social function. Here, we explored whether Ca_V 1.3 plays a role in these behaviors. We found that Ca_V 1.3 knockout mice have deficits in r

SUBMITTER: Lauffer M 

PROVIDER: S-EPMC9744532 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature