The Endocannabinoid System and Eating Behaviours: a Review of the Current State of the Evidence.

ABSTRACT:

Purpose of the review

The endocannabinoid system (ENS) has emerged as an important factor in food intake and may have implications for nutrition research. The objective of the current report is to summarise the available evidence on the ENS and eating behaviour from both animal and human studies.

Recent findings

The literature reviewed demonstrates a clear link between the ENS and eating behaviours. Overall, studies indicate that 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (AEA) via cannabinoid receptor-1 (CNR1) binding may stimulate hunger and food intake while oleylethanolamide (OEA) may inhibit hunger. Mechanisms of these associations are not yet well understood, although the evidence suggests that there may be interactions with other physiological system

SUBMITTER: Aguilera Vasquez N 

PROVIDER: S-EPMC9750929 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature