The RNA-binding protein RBP33 dampens non-productive transcription in trypanosomes.

ABSTRACT: In-depth analysis of the transcriptomes of several model organisms has revealed that genomes are pervasively transcribed, giving rise to an abundance of non-canonical and mainly antisense RNA polymerase II-derived transcripts that are produced from almost any genomic context. Pervasive RNAs are degraded by surveillance mechanisms, but the repertoire of proteins that control the fate of these non-productive transcripts is still incomplete. Trypanosomes are single-celled eukaryotes that show constitutive RNA polymerase II transcription and in which initiation and termination of transcription occur at a limited number of sites per chromosome. It is not known whether pervasive transcription exists in organisms with unregulated RNA polymerase II activity, and which factors could be involved in

SUBMITTER: Gomez-Linan C 

PROVIDER: S-EPMC9757043 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature