Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus.

ABSTRACT: Recent evidence indicates that ultraviolet (UV) exposure of the skin can affect brain functions such as learning and memory, addictive behavior, and hippocampal neurogenesis. These changes are closely associated with hippocampal function, which plays a pivotal role in learning and memory formation. However, the molecular mechanisms underlying these UV-induced skin-brain interactions remain unclear. To elucidate the molecular signature associated with UV-induced neurobehavioral changes, we analyzed the hippocampal transcriptome in a well-established mouse skin aging model, which showed thickened skin and impaired hippocampal memory. Transcriptome analysis revealed that significantly downregulated genes in UV-irradiated mice are enriched in neuroimmune-related signaling pathways. Furthermore

SUBMITTER: Yoon KN 

PROVIDER: S-EPMC9768969 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature