Colocalization Analysis of Cytoplasmic Actin Isoforms Distribution in Endothelial Cells.

ABSTRACT: Actin cytoskeleton is an essential component of living cells and plays a decisive role in many cellular processes. In mammals, β- and γ-actin are cytoplasmic actin isoforms in non-muscle cells. Despite minor differences in the amino acid sequence, β- and γ-actin localize in different cell structures and perform different functions. While cytoplasmic β-actin is involved in many intracellular processes including cell contraction, γ-actin is responsible for cell mobility and promotes tumor transformation. Numerous studies demonstrate that β- and γ-actin are spatially separated in the cytoplasm of fibroblasts and epithelial cells; this separation is functionally determined. The spatial location of β/γ-actin in endothelial cells is still a subject for discussion. Using super-resolution microsco

SUBMITTER: Shakhov AS 

PROVIDER: S-EPMC9775052 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature