Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis.

ABSTRACT:

Background

It is generally believed that complement system is strongly associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, complement system contains a variety of complement components, and the relationship between complement components and the risk and severity of NAFLD is inconsistent. The aim of this meta-analysis was to evaluate the association of complement components with the risk and severity of NAFLD.

Methods

We searched PubMed, Embase, Cochrane Library, Google Scholar, Scopus, and ZhiWang Chinese databases from inception to May 2022 for observational studies reporting the risk of NAFLD with complement components. Random-effects meta-analysis was used to obtain pooled estimates of the effect due to heterogeneity.

Results

We identifie

SUBMITTER: Zhao J 

PROVIDER: S-EPMC9782972 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature