Drug Repositioning Applied to Cardiovascular Disease in Mucopolysaccharidosis.
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ABSTRACT:
SUBMITTER: Villalba Silva GC
PROVIDER: S-EPMC9784427 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
Drug Repositioning Applied to Cardiovascular Disease in Mucopolysaccharidosis.
Villalba Silva Gerda Cristal GC Steindorff Thiago T Silvestri Schuh Roselena R Cardoso Flores Natalia N Matte Ursula U
Life (Basel, Switzerland) 20221212 12
Mucopolysaccharidoses (MPS) are genetic metabolic diseases characterized by defects in the activity of lysosomal hydrolases. In MPS, secondary cell disturbance affects pathways related to cardiovascular disorders. Hence, the study aimed to identify MPS-related drugs targeting cardiovascular disease and select a list of drugs for repositioning. We obtained a list of differentially expressed genes and pathways. To identify drug perturbation-driven gene expression and drug pathways interactions, we ...[more]
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