Dataset Information

Time from last immunity event against infection during Omicron-dominant period in Malaysia.

ABSTRACT:

Objectives

To study the incidence of Omicron infections in Malaysia and the exposures that could reduce the hazard of attaining Omicron infection.

Methods

We used a multicenter, prospective cohort to study 482 healthcare workers vaccinated with two and three doses of BNT162b2 for SARS-CoV-2 infection during the Omicron-dominant period in Malaysia.

Results

Between January 31 and July 31, 2022, the cumulative incidence was 44.6% (95% CI 40.2-49.1%), and the incidence rate was 3.33 (95% CI 2.91-3.80) per 1000 person-days. Our study found that protection against Omicron infection was significantly higher for persons with previous SARS-CoV-2 infection (hazard ratio [HR] 0.41, 95% CI 0.27-0.62) and persons with a more recent immunity event (<30 days [reference] vs >90 days, HR 3.82, 95%CI 1.34-10.90) from the beginning of the Omicron period.

Conclusion

Pre-Omicron natural infection and a recent immunity event protect against future Omicron infections.

SUBMITTER: Yang SL

PROVIDER: S-EPMC9791788 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

Time from last immunity event against infection during Omicron-dominant period in Malaysia.

Yang Su Lan SL Ripen Adiratna Mat AM Lee Jen Ven JV Koh Karina K Yen Chia How CH Chand Avinash Kumar AK Abdul Rahim Nur Aisyah Binti NAB Gokilavanan Varaalakshmy V Mohamed Nik Nur Eliza Binti NNEB Sevalingam Raj Kumar A/L RKA Peariasamy Kalaiarasu M KM

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20221226

<h4>Objectives</h4>To study the incidence of Omicron infections in Malaysia and the exposures that could reduce the hazard of attaining Omicron infection.<h4>Methods</h4>We used a multicenter, prospective cohort to study 482 healthcare workers vaccinated with two and three doses of BNT162b2 for SARS-CoV-2 infection during the Omicron-dominant period in Malaysia.<h4>Results</h4>Between January 31 and July 31, 2022, the cumulative incidence was 44.6% (95% CI 40.2-49.1%), and the incidence rate was ...[more]

PMID: 36581187

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Project description:BackgroundSeroprevalence and the proportion of people with neutralizing activity (functional immunity) against SARS-CoV-2 variants were high in early 2022. In this prospective, population- based, multi-region cohort study, we assessed the development of functional and hybrid immunity (induced by vaccination and infection) in the general population during this period of high incidence of infections with Omicron variants.MethodsWe randomly selected and assessed individuals aged ≥16 years from the general population in southern (n = 739) and north-eastern (n = 964) Switzerland in March 2022. We assessed them again in June/July 2022, supplemented with a random sample from western (n = 850) Switzerland. We measured SARS-CoV-2 specific IgG antibodies and SARS-CoV-2 neutralizing antibodies against three variants (ancestral strain, Delta, Omicron).ResultsSeroprevalence remained stable from March 2022 (97.6%, n = 1894) to June/July 2022 (98.4%, n = 2553). In June/July, the percentage of individuals with neutralizing capacity against ancestral strain was 94.2%, against Delta 90.8% and against Omicron 84.9%, and 50.6% developed hybrid immunity. Individuals with hybrid immunity had highest median levels of anti-spike IgG antibodies titres [4518 World Health Organization units per millilitre (WHO U/mL)] compared with those with only vaccine- (4304 WHO U/mL) or infection- (269 WHO U/mL) induced immunity, and highest neutralization capacity against ancestral strain (hybrid: 99.8%, vaccinated: 98%, infected: 47.5%), Delta (hybrid: 99%, vaccinated: 92.2%, infected: 38.7%) and Omicron (hybrid: 96.4%, vaccinated: 79.5%, infected: 47.5%).ConclusionsThis first study on functional and hybrid immunity in the Swiss general population after Omicron waves showed that SARS-CoV-2 has become endemic. The high levels of antibodies and neutralization support the emerging recommendations of some countries where booster vaccinations are still strongly recommended for vulnerable persons but less so for the general population.

Dataset Information

Time from last immunity event against infection during Omicron-dominant period in Malaysia.

Objectives

Methods

Results

Conclusion

Publications

Time from last immunity event against infection during Omicron-dominant period in Malaysia.

Similar Datasets

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