Improving multiparametric MR-transrectal ultrasound guided fusion prostate biopsies with hyperpolarized ¹³ C pyruvate metabolic imaging: A technical development study.

ABSTRACT:

Purpose

To develop techniques and establish a workflow using hyperpolarized carbon-13 (¹³ C) MRI and the pyruvate-to-lactate conversion rate (k_PL ) biomarker to guide MR-transrectal ultrasound fusion prostate biopsies.

Methods

The integrated multiparametric MRI (mpMRI) exam consisted of a 1-min hyperpolarized ¹³ C-pyruvate EPI acquisition added to a conventional prostate mpMRI exam. Maps of k_PL values were calculated, uploaded to a picture archiving and communication system and targeting platform, and displayed as color overlays on T₂ -weighted anatomic images. Abdominal radiologists identified ¹³ C research biopsy targets based on the general recommendation of focal lesions with k_PL  >0.02(s^-1

SUBMITTER: Chen HY 

PROVIDER: S-EPMC9794017 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature