Ontology highlight
ABSTRACT:
SUBMITTER: Osma-Garcia IC
PROVIDER: S-EPMC9794549 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Cell reports 20221201 12
B cell lymphopoiesis requires dynamic modulation of the B cell transcriptome for timely coordination of somatic mutagenesis and DNA repair in progenitor B (pro-B) cells. Here, we show that, in pro-B cells, the RNA-binding proteins T cell intracellular antigen 1 (TIA1) and TIA1-like protein (TIAL1) act redundantly to enable developmental progression. They are global splicing regulators that control the expression of hundreds of mRNAs, including those involved in DNA damage repair. Mechanistically ...[more]