Randomised trial of population-based BRCA testing in Ashkenazi Jews: long-term secondary lifestyle behavioural outcomes.

ABSTRACT:

Objective

Ashkenazi-Jewish (AJ) population-based BRCA testing is acceptable, cost-effective and amplifies primary prevention for breast & ovarian cancer. However, data describing lifestyle impact are lacking. We report long-term results of population-based BRCA testing on lifestyle behaviour and cancer risk perception.

Design

Two-arm randomised controlled trials (ISRCTN73338115, GCaPPS): (a) population-screening (PS); (b) family history (FH)/clinical criteria testing.

Setting

North London AJ-population.

Population/sample

AJ women/men >18 years.

Exclusions

prior BRCA testing or first-degree relatives of BRCA-carriers.

Methods

Participants were recruited through self-referral. All participants received informed pre-test genetic counselling. The inte

SUBMITTER: Burnell M 

PROVIDER: S-EPMC9796935 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature