Dataset Information

Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study.

ABSTRACT:

Background

Age is a leading contributor to the liver fibrosis rate and a gradual deterioration of optical function, but this association in older populations is still under-explored. The present study aimed to explore the link between vascular and neural retinal characteristics and the risk of liver fibrosis in 731 older adults from the population-based Salus in Apulia study.

Methods

Retinal features were obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A). Liver fibrosis risk was taken as the fibrosis-4 (FIB-4) score. Generalized linear models (logistic regression) were used to estimate the association effect between each unit increase of OCT and OCT-A parameters as independent variables and a FIB-4 ≥ 2.67 score as an outcome. Generalized additive models were used to assess the non-linear association between OCT-A features and the linear FIB-4 score.

Results

Increased gangliar cell complex (GCC) thickness was inversely associated with a FIB-4 score above the cut-off in both the raw model (OR: 0.98; 95% CI: 0.96-0.99; SE: 0.01) and after adjustment for age, sex, education, hypertension, diabetes, total cholesterol, and triglycerides (OR: 0.98; 95% CI: 0.97-0.99; SE: 0.01).

Conclusion

Our findings add to the growing volume of scientific literature demonstrating that liver fibrosis is associated with retinal neurodegeneration. This study raises a number of new questions, including whether OCT-A may be used to track the progression of metabolic abnormalities and define exact thresholds for predicting and classifying liver disease.

SUBMITTER: Lampignano L

PROVIDER: S-EPMC9798127 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study.

Lampignano Luisa L Niro Alfredo A Castellana Fabio F Bortone Ilaria I Zupo Roberta R Tirelli Sarah S Tatoli Rossella R Griseta Chiara C De Nucci Sara S Sila Annamaria A De Pergola Giovanni G Conte Caterina C Alessio Giovanni G Boscia Francesco F Sborgia Giancarlo G Giannelli Gianluigi G Sardone Rodolfo R

Frontiers in neuroscience 20221215

<h4>Background</h4>Age is a leading contributor to the liver fibrosis rate and a gradual deterioration of optical function, but this association in older populations is still under-explored. The present study aimed to explore the link between vascular and neural retinal characteristics and the risk of liver fibrosis in 731 older adults from the population-based Salus in Apulia study.<h4>Methods</h4>Retinal features were obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A ...[more]

PMID: 36590297

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Project description:Background & aimsLiver disease is the third leading cause of death in patients with cystic fibrosis (CF), but features of patients with CF, severe liver disease, and portal hypertension have not been characterized fully.MethodsWe performed a retrospective analysis of data from 561 patients with CF (63% male, 99% with pancreatic insufficiency), liver disease (hepatic parenchymal abnormalities consistent with cirrhosis, confirmed by imaging), and portal hypertension (esophageal varices, portosystemic collaterals, or splenomegaly), with no alternate causes of liver disease. All patients were enrolled in the Genetic Modifier Study of Severe CF Liver Disease at 76 international centers, from January 1999 through July 2013.ResultsMale patients were diagnosed with liver disease at a younger age than female patients (10 vs 11 y; P = .01). Splenomegaly was observed in 99% of patients and varices in 71%. Levels of liver enzymes were near normal in most patients. Thrombocytopenia affected 70% of patients and was more severe in patients with varices (88 × 10(9)/L vs 145 × 10(9)/L; P < .0001). Ninety-one patients received liver transplants (16%), at a median age of 13.9 years. Compared with patients who did not receive liver transplants, patients who received liver transplants had lower platelet counts (78 × 10(9)/L vs 113 × 10(9)/L; P < .0001), higher international normalized ratios (P < .0001), and lower levels of albumin (P = .0002). The aminotransferase to platelet ratio index (APRi) and fibrosis index based on 4 factor (FIB-4) values were higher than the diagnostic thresholds for CF liver disease in 96% and in 90% of patients, respectively. Patients who received liver transplants or who had varices had higher APRi and FIB-4 values than patients who did not.ConclusionsIn patients with CF, severe liver disease develops early in childhood (approximately 10 years of age), and is more common in boys than in girls. Patients with varices and those who receive liver transplants have more abnormal platelet counts and APRi and FIB-4 scores.

Dataset Information

Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study.

Background

Methods

Results

Conclusion

Publications

Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study.

Similar Datasets

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