Positive memory increases cataplexy-like behaviors in narcolepsy mice as revealed using conditioned place preference test.

ABSTRACT:

Background

Cataplexy is a loss of muscle tone that can lead to postural collapse, disturbing the daily life of narcolepsy patients; it is often triggered by positive emotions such as laughter in human patients. Narcolepsy model mice also show cataplexy, and its incidence increases in response to positive emotion-inducing stimuli such as chocolate and female courtship. Although such observation indicates a positive emotion-related nature of cataplexy in narcolepsy mice, they also show cataplexy without any apparent triggering stimulus ~ (spontaneous cataplexy). Therefore, we hypothesized that some spontaneous cataplexy in narcoleptic mice might indicate the remembering of happy moments.

Results

To test our hypothesis, we did a conditioned place preference test on orexin/hypoc

SUBMITTER: Yoshida M 

PROVIDER: S-EPMC9798626 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature