Adjunctive Pharmacotherapy Use in Patients With Ileal Pouch-Anal Anastomosis (IPAA).

ABSTRACT:

Background

This study evaluated the prevalence of adjunctive pharmacotherapies use among ileal pouch-anal anastomosis (IPAA) patients.

Methods

The IBD Partners database was queried to compare IPAA patients with and without pouch-related symptoms (PRS). Within the cohort of patients with PRS, patient reported outcomes were compared among opioid, nonsteroidal anti-inflammatory drug (NSAID), and probiotic users.

Results

There were no differences in patient reported outcomes based on NSAID or probiotic usage. Opioid users reported increased bowel frequency, urgency, poor general well-being, abdominal pain, and depression (P < 0.05 for all variables).

Conclusions

In IPAA patients with PRS, opioid use, but not NSAIDs or probiotics, was associated with a higher

SUBMITTER: Nyabanga CT 

PROVIDER: S-EPMC9802495 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature