Swimming exercise is a promising early intervention for autism-like behavior in Shank3 deletion rats.

ABSTRACT:

Introduction

SHANK3 is an important excitatory postsynaptic scaffold protein, and its mutations lead to genetic cause of neurodevelopmental diseases including autism spectrum disorders (ASD), Philan McDermid syndrome (PMS), and intellectual disability (ID). Early prevention and treatment are important for Shank3 gene mutation disease. Swimming has been proven to have a positive effect on neurodegenerative diseases.

Methods

Shank3 gene exon 11-21 knockout rats were intervened by a 40 min/day, 5 day/week for 8-week protocol. After the intervention, the rats were tested to behavioral measures such as learning and memory, and the volume and H-spectrum of the brain were measured using MRI; hippocampal dendritic spines were measured using Golgi staining and laser confocal.

Resu

SUBMITTER: Xu D 

PROVIDER: S-EPMC9804047 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature