Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies.
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ABSTRACT: Background
T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown.Objectives
To investigate whether T-cell activation and exhaustion persist and are associated with prolonged respiratory dysfunction and death after hospitalization for COVID-19.Methods
Plasma and serum from two Norwegian cohorts of hospitalized patients with COVID-19 (n = 414) were analyzed for soluble (s) markers of T-cell activation (sCD25) and exhaustion (sTim-3) during hospitalization and follow-up.Results
Both markers were strongly associated with acute respiratory failure, but only sTim-3 was independently associated with 60-day mortality. Levels of sTim-3 remained elevated 3 and 12 months after hospitalization and were associated with pulmonary radiological pathology after 3 months.Conclusion
Our findings suggest prolonged T-cell exhaustion is an important immunological sequela, potentially related to long-term outcomes after severe COVID-19.
SUBMITTER: Troseid M
PROVIDER: S-EPMC9805032 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies.
Trøseid Marius M Dahl Tuva B TB Holter Jan C JC Kildal Anders B AB Murphy Sarah L SL Yang Kuan K Quiles-Jiménez Ana A Heggelund Lars L Müller Karl Erik KE Tveita Anders A Michelsen Annika E AE Bøe Simen S Holten Aleksander R AR Hoel Hedda H Mathiessen Alexander A Aaløkken Trond M TM Fevang Børre B Granerud Beathe K BK Tonby Kristian K Henriksen Katerina N KN Lerum Tøri V TV Müller Fredrik F Skjønsberg Ole H OH Barratt-Due Andreas A Dyrhol-Riise Anne M AM Aukrust Pål P Halvorsen Bente B Ueland Thor T
Journal of internal medicine 20220818 5
<h4>Background</h4>T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown.<h4>Objectives</h4>To investigate whether T-cell activation and exhaustion persist and are associated with prolonged respiratory dysfunction and death after hospitalization for COVID-19.<h4>Methods</h4>Plasma and serum from two Norwegian cohorts of hospitalized patients with COVID-19 (n = 414) were a ...[more]
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