Antibody Response to HML-2 May Be Protective in Amyotrophic Lateral Sclerosis.

ABSTRACT:

Objectives

Reactivation of HERV-K(HML-2) has been found in subsets of individuals with amyotrophic lateral sclerosis (ALS). This study examines the antibody response against HML-2 in ALS and analyzes its clinical relevance.

Methods

Antibodies to HML-2 envelope (env) were analyzed using a peptide array for epitope mapping and by a peptide enzyme-linked immunosorbent assay (ELISA) in 242 healthy donors, and 243 ALS and 85 multiple sclerosis (MS) individuals. Extracellular levels of HML-2 were analyzed by digital polymerase chain reaction (PCR).

Results

Antibodies in the sera of ALS individuals recognized more HML-2 env peptides compared to healthy controls (p < 0.0001). ALS individuals had higher levels of HML-2 than healthy donors (p = 0.02) and higher antibody levels

SUBMITTER: Garcia-Montojo M 

PROVIDER: S-EPMC9805205 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature