High-dose cephalexin for cellulitis: a pilot randomized controlled trial.

ABSTRACT:

Background

Up to 3% of all Emergency Department (ED) visits are due to skin and soft tissue infections such as non-purulent cellulitis. The current treatment failure rate is approximately 20%. Evidence is lacking regarding the optimal outpatient management of cellulitis.

Objectives

To evaluate the feasibility of a randomized trial comparing high-dose (1000 mg) to standard-dose (500 mg) cephalexin to treat ED patients with cellulitis.

Methods

A parallel arm double-blind randomized controlled pilot trial conducted at two EDs in Canada. Eligible participants were adults (age ≥ 18 years) presenting to the ED with non-purulent cellulitis and determined by the treating emergency physician to be eligible for outpatient management with oral antibiotics. Participants were rand

SUBMITTER: Yadav K 

PROVIDER: S-EPMC9807092 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature