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Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans.


ABSTRACT: Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference between chronological and physiological ages at the transcriptomic level has been a challenge because of its complexity. We analyzed the transcriptomic features associated with physiological and chronological aging using Caenorhabditis elegans as a model. Many structural and functional transcript elements, such as noncoding RNAs and intron-derived transcripts, were up-regulated with chronological aging. In contrast, mRNAs with many biological functions, including RNA processing, were down-regulated with physiological aging. We also identified an age-dependent increase in the usage of distal 3' splice sites in mRNA transcripts as a biomarker of physiological aging. Our study provides crucial information for dissecting chronological and physiological aging at the transcriptomic level.

SUBMITTER: Ham S 

PROVIDER: S-EPMC9808617 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature

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Systematic transcriptome analysis associated with physiological and chronological aging in <i>Caenorhabditis elegans</i>.

Ham Seokjin S   Kim Sieun S SS   Park Sangsoon S   Kim Eun Ji E EJE   Kwon Sujeong S   Park Hae-Eun H HH   Jung Yoonji Y   Lee Seung-Jae V SV  

Genome research 20221109 11-12


Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference between chronological and physiological ages at the transcriptomic level has been a challenge because of its complexity. We analyzed the transcriptomic features associated with physiological and chronological aging using <i>Caenorhabditis elegans</i> as a  ...[more]

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