Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans.

ABSTRACT: Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference between chronological and physiological ages at the transcriptomic level has been a challenge because of its complexity. We analyzed the transcriptomic features associated with physiological and chronological aging using Caenorhabditis elegans as a model. Many structural and functional transcript elements, such as noncoding RNAs and intron-derived transcripts, were up-regulated with chronological aging. In contrast, mRNAs with many biological functions, including RNA processing, were down-regulated with physiological aging. We also identified

SUBMITTER: Ham S 

PROVIDER: S-EPMC9808617 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature