Photonic Technology for In Vivo Monitoring of Hypoxia-Ischemia.

ABSTRACT: Surveillance of physiological parameters of newborns during delivery triggers medical decision-making, can rescue life and health, and helps avoid unnecessary cesareans. Here, the development of a photonic technology for monitoring perinatal asphyxia is presented and validated in vivo in a preclinical stage. Contrary to state of the art, the technology provides continuous data in real-time in a non-invasive manner. Moreover, the technology does not rely on a single parameter as pH or lactate, instead monitors changes of the entirety of physiological parameters accessible by Raman spectroscopy. By a fiber-coupled Raman probe that is in controlled contact with the skin of the subject, near-infrared Raman spectra are measured and analyzed by machine learning algorithms to develop classificati

SUBMITTER: Olaetxea I 

PROVIDER: S-EPMC9811478 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature