Biodegradable MnO₂-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity.

ABSTRACT: Immune checkpoint blockade (ICB) is emerging as a promising therapeutic approach for clinical treatment against various cancers. However, ICB based monotherapies still suffer from low immune response rate due to the limited and exhausted tumor-infiltrating lymphocytes as well as tumor immunosuppressive microenvironment. In this work, the cell membrane with surface displaying PD-1 proteins (PD1-CM) was prepared for immune checkpoint blockade, which was further combined with multifunctional and biodegradable MnO₂ for systematic and robust antitumor therapy. The MnO₂-based gene-engineered nanocomposites can catalyze the decomposition of abundant H₂O₂ in TME to generate O₂, which can promote the intratumoral infiltration of T cells, and th

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9812708 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature