Epigenetic and genetic investigation of SOCS-1 gene in patients with multiple myeloma.

ABSTRACT:

Background

The suppressor of cytokine signaling-1 (SOCS-1) functions to induce an appropriate immune response and is an essential physiological regulator of interferon signaling. DNA methylation involves adding a methyl group to the carbon 5 position of cytosine. Besides comparing SOCS-1 gene methylation status between patients with multiple myeloma (MM) and healthy controls, this study also aimed to demonstrate the effect of SOCS-1 gene distribution and the effect of methylation of SOCS-1 on progression-free survival (PFS) and overall survival (OS).

Methods

This study included 120 patients diagnosed with MM between January 2018 and 2020 and 80 healthy individuals. The distribution of the SOCS-1 genotypes was statistically compared between MM patients and healthy controls. A

SUBMITTER: Tuncel FC 

PROVIDER: S-EPMC9812727 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature