Effects of cannabinoids in Parkinson's disease animal models: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Cannabis has been proposed as a potential treatment for Parkinson's disease (PD) due to its neuroprotective benefits. However, there has been no rigorous review of preclinical studies to evaluate any potential treatment effect. This systematic review was undertaken to provide evidence in support or against a treatment effect of cannabinoids in animal models of PD.

Methods

Databases were searched for any controlled comparative studies that assessed the effects of any cannabinoid, cannabinoid-based treatment or endocannabinoid transport blocker on behavioural symptoms in PD animal models.

Results

A total of 41 studies were identified to have met the criteria for this review. 14 of these studies were included in meta-analyses of rotarod, pole and open field te

SUBMITTER: Urbi B 

PROVIDER: S-EPMC9812814 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature