Impaired structural and reserved functional topological organizations of brain networks in Parkinson’s disease with freezing of gait

ABSTRACT:

Background

Freezing of gait (FOG) is a common disabling motor disturbance in Parkinson’s disease (PD). Our study aimed to probe the topological organizations of structural and functional brain networks and their coupling in FOG.

Methods

In this cross-sectional retrospective study, a total of 30 PD patients with FOG (PD-FOG), 40 patients without FOG, and 25 healthy controls (HCs) underwent clinical assessments and magnetic resonance imaging (MRI) scanning. Large-scale structural and functional brain networks were constructed. Subsequently, global and nodal graph theoretical properties and functional-structural coupling were investigated. Finally, correlations between the altered brain topological properties and freezing severity were analyzed in PD-FOG.

Results

Fo

SUBMITTER: Wang L 

PROVIDER: S-EPMC9816763 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature