The localization of the alkaloids in Coptis chinensis rhizome by time-of-flight secondary ion mass spectrometry.

ABSTRACT:

Background

Understanding the spatial distribution of active compounds can effectively evaluate the quality of decoction pieces of traditional Chinese medicine (TCM). Traditional methods are economical and practical but lack chemical information on the original distribution. Time-of-flight secondary ion mass spectrometry (TOF-SIMS), with the advantage of non-destructive detection of samples, can directly analyze the distribution of chemical compounds on the surface of various samples.

Methods

In this study, TOF-SIMS image analysis technology was used to detect TCM for the first time. Taking Coptis rhizome (CR) as an example, a commonly used TCM, the distribution of the compounds in the cross-section of CR was studied. Meanwhile, ultra-high-performance liquid chromatography co

SUBMITTER: He F 

PROVIDER: S-EPMC9816869 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature