PHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS.

ABSTRACT:

Background

Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death worldwide. Plant homeodomain (PHD)-finger domain protein PHF5A has been demonstrated to play a promoting role in a variety of cancers. This study aimed to clarify the role of PHF5A in the progression of GC and its potential mechanism of action.

Methods

Immunohistochemical staining experiments were performed based on tissues from clinical GC patients to reveal PHF5A expression. A series of functional experiments in vitro and in vivo were used to clarify the role of PHF5A in GC.

Results

Clinically, PHF5A was abundantly expressed in GC and existed clinical value indicating poor prognosis. In addition, GC cells with knockdown of PHF5A expression showed slowed pro

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC9817416 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature