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Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives.

ABSTRACT: Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to ¹H and ³¹P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA conditions, and by the PH-ECHO-INEPT+ pulse sequence of NMR spectroscopy, resulted in a very high signal amplification, which is among the largest for parahydrogen-induced nuclear polarization transfer to the ³¹P nucleus.

SUBMITTER: Zlobina VV

PROVIDER: S-EPMC9820518 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives.

Zlobina Veronika V VV Kiryutin Alexey S AS Nikovskiy Igor A IA Artyushin Oleg I OI Kozinenko Vitaly P VP Peregudov Alexander S AS Yurkovskaya Alexandra V AV Novikov Valentin V VV

International journal of molecular sciences 20221229 1

Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to 1H and 31P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA condition ...[more]

PMID: 36613997

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