Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3.

ABSTRACT:

Background

Children with asthma are at risk for low lung function extending into adulthood, but understanding of clinical predictors is incomplete.

Objective

We sought to determine phenotypic factors associated with FEV₁ throughout childhood in the Severe Asthma Research Program 3 pediatric cohort.

Methods

Lung function was measured at baseline and annually. Multivariate linear mixed-effects models were constructed to assess the effect of baseline and time-varying predictors of prebronchodilator FEV₁ at each assessment for up to 6 years. All models were adjusted for age, predicted FEV₁ by Global Lung Function Initiative reference equations, race, sex, and height. Secondary outcomes included postbronchodilator FEV₁ and prebro

SUBMITTER: Gaffin JM 

PROVIDER: S-EPMC9825637 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature