Effects of pre-eclampsia on HDL-mediated cholesterol efflux capacity after pregnancy.

ABSTRACT:

Background and aims

Preeclampsia (PE) is associated with life-long increased risk of cardiovascular disease. One of the main protective functions of high-density lipoprotein (HDL) is its role in reverse cholesterol transport. HDL-mediated cholesterol efflux capacity (CEC) is decreased during pregnancy in women with PE. Whether this persists postpartum is unknown.

Methods

Basal and transporter-specific CEC were determined 6 months postpartum in women who had a normotensive (n = 44) or a PE (n = 42) pregnancy. CEC was also measured in 23 normotensive and 20 PE women for whom samples were collected 24 months postpartum. Basal, ATP-binding cassette transporter-A1 (ABCA1)- and -G1 (ABCG1)-specific CEC were primarily determined using Chinese hamster ovary cells stably expressing h

SUBMITTER: Kockx M 

PROVIDER: S-EPMC9833242 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature