Impaired cell-cell communication and axon guidance because of pulmonary hypoperfusion during postnatal alveolar development.

ABSTRACT:

Background

Pulmonary hypoperfusion is common in children with congenital heart diseases (CHDs) or pulmonary hypertension (PH) and causes adult pulmonary dysplasia. Systematic reviews have shown that some children with CHDs or PH have mitigated clinical outcomes with COVID-19. Understanding the effects of pulmonary hypoperfusion on postnatal alveolar development may aid in the development of methods to improve the pulmonary function of children with CHDs or PH and improve their care during the COVID-19 pandemic, which is characterized by cytokine storm and persistent inflammation.

Methods and results

We created a neonatal pulmonary hypoperfusion model through pulmonary artery banding (PAB) surgery at postnatal day 1 (P1). Alveolar dysplasia was confirmed by gross and histolog

SUBMITTER: Li D 

PROVIDER: S-EPMC9833865 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature